Risks of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant usage of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may possibly lead to a rise in tramadol plasma stages and also a lessen within the levels of the Lively metabolite, M1.Teach sufferers and caregiv